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韩琳
发布时间:2018年01月05日 15:10    作者:李鸥    点击:[]

 韩琳,女,山东大学齐鲁青年学者,山东省杰出青年基金获得者,目前为必威体育手机端下载教授。

主要从事微电子与生物医学或海洋环境交叉领域的研究,目前承担国家自然基金青年项目、国家重点研发计划(课题负责人)“高增敏金属纳米结构材料与聚集体生化传感器研究”、山东省杰出青年基金、山东省重大科技创新项目课题等多项省部级项目,并获得2019年山东大学青年交叉科学创新群体项目支持。在包括Nucleic Acids ResearchSmallNanoscale, Npj 2D Materials and Applications, Scientific Reports, Applied Physics Letters, IEEE Electronic Devices Letts, PNAS, Nano Letters, ACS Nano等的国际期刊发表论文40余篇,申请美国专利9项,中国专利8项,国际专利2项,其中授权美国专利4项。

在普林斯顿大学电子工程系获得博士学位,在微纳加工方面积累了丰富的经验。博士毕业后加入耶鲁大学生物医学工程系,结合自身的电子工程技术,研发用于单细胞生物信息分析的微流控芯片系统,并取得多项创新成果。201510月被生物技术公司 Isoplexis聘为首席科学家,继续研发高通量单细胞分泌蛋白芯片,设计制备了一种高通量单细胞功能因子分析平台,可对数以千计的活体单细胞所分泌的多种功能因子进行定量检测,在免疫细胞治疗方面具有非常重要的应用价值。

目前课题组的主要研究方向包括:1、单细胞分析芯片与系统;2、生物分子尤其是疾病相关标记物(外泌体、miRNADNA片段、抗原、抗体等)的高灵敏、高可靠、高通量检测;3、基于荧光、拉曼、新型电子器件、电化学的检测芯片、系统和小型装备的研发;4、环境污染物的检测,比如重金属离子、抗生素、毒素等的快速检测。基于10余年的微纳加工经验,在半导体材料生长、器件与电路设计及微加工制备、湿法刻蚀、激光剥离、晶圆健合、晶圆研磨和抛光等工艺,以及材料器件分析和测试方面具有坚实的基础。课题组具备从芯片设计、加工、到系统和小型设备搭建、信号检测分析等全套的平台条件。

E-mail: hanlin@sdu.edu.cn lin_han22@163.com

Abstract:

Prof. Lin Han, Qilu young scholar, Shandong University;  winners of National Science Fund for Outstanding Young Scholars in Shandong Province; Professor of Marine institute of school, Shandong University.

Prof. Han majored in microelectronics, biomedical interdisciplinary field. She focuses on the research in the interdisciplinary of bio-molecular information and microelectronics, study the single-celled or extremely low concentration biomolecules through microfluidic platform. The advantages of microfluidic platform include high throughput, small sample volume consuming, high reliability and sensitivity. Prof. Han has published more than 40 scientific papers in international journals, including Nucleic Acids ResearchSmallNanoscale, Npj 2D Materials and Applications, Scientific Reports, Applied Physics Letters, IEEE Electronic Devices Letts, PNAS, Nano Letters, ACS Nano, etc. She has applied for 9 U.S. patents, 8 Chinese patents, and 2 international patents, including 4 authorized USA patents.

Prof. Han got her PhD degree in the Department of Electrical Engineering at Princeton University, and is experienced at micro- and nano-fabrication. She joined Department of Biomedical Engineering at Yale University after Ph.D graduation, and continued her research in the development for single-cell bio-information analysis system based on microfluidic chip. She took advantages of her microelectronic technology and biology knowledge, and achieved a number of innovations. In October 2015, Prof. Han was appointed as a chief scientist in a biotech company of Isoplexis. She has contributed greatly to develop high flux single-cell secretory protein chip, and designed high-throughput microfluidics, which could detect multiple cytokines from living single cells. The technique has important applications in immune cell therapy.

Her research group mainly focus on the following studies: 1. High throughput chip and system for single cell analysis; 2. Ultrasensitive, high-reliable, and high-throughput detection of bio-molecules, especially disease-related biomarkers (exosome, miRNA, DNA, antigen, antibody etc.); 3. Development of sensing chip, system and equipment based on fluorescence, Raman spectrum, new electronic devices, and electrochemical approaches; 4. New methods for environmental contaminations monitoring, including heavy metal ions, antibiotics, toxins, and red-tide algae etc.

 

学习工作经历:

普林斯顿大学电子工程系博士(2011

耶鲁大学生物医学工程系博士后(2011-2015

耶鲁大学生物医学工程系副研究员(2015

美国Isoplexis公司首席科学家(2015-2016

山东省杰出青年基金(2017

山东大学齐鲁青年学者(2016

山东大学教授(2016-

Experiences:

Ph.D., Department of Electrical Engineering, Princeton University (2011)

Postdoctoral Fellow, Department of Biomedical Engineering, Yale University (2011-2015)

Associate Research Scientist, Department of Biomedical engineering, Yale University (2015)

Chief scientist, Isoplexis Company, USA (2015-2016)

Outstanding Youth Funding, Shandong Province (2018)

Qilu Young Scholar, Shandong University (2016)

Professor, Shandong University (2016-)

研究方向:利用微电子、纳米材料、分析化学与生命科学的交叉融合,开创交叉研究特色学科,突破卡脖子的关键技术,开发国家急需的生物传感检测分析芯片、系统与装备。

  1. 单细胞分析芯片与系统;

  2. 生物分子尤其是疾病相关标记物(外泌体、miRNADNA片段、抗原、抗体等)的高灵敏、高可靠、高通量检测;

  3. 基于荧光、拉曼、新型电子器件、电化学的检测芯片、系统和小型装备的研发;

  4. 环境污染物的检测,比如重金属离子、抗生素、毒素、赤潮藻等的快速检测。

Research Interests:

  1. High throughput chip and system for single cell analysis

  2. Ultrasensitive, high-reliable, and high-throughput detection of bio-molecules, especially disease-related biomarkers (exosome, miRNA, DNA, antigen, antibody etc.);

  3. Development of sensing chip, system and equipment based on fluorescence, Raman spectrum, new electronic devices, and electrochemical approaches

  4. New methods for environmental contaminations monitoring, including heavy metal ions, antibiotics, toxins, and red-tide algae etc.

 

代表性著作/Selected Publications

  1. Yanhao Wang, Jianwei Gao, Bin Wei, Yingkuan Han, Chao Wang, Yakun Gao, Hong Liu*, Lin Han*, Yu Zhang*, Depression of ambient effect in multilayer InSe transistor and a strategy toward to stable 2D-based optoelectronic applications, Nanoscale, accepted.

  2. Jianfeng Jiang, Fanqi Meng, Qilin Cheng, Aizhu Wang, Yuke Chen, Jie Qiao, Jinbo Pang, Weidong Xu, Hao Ji, Yu Zhang, Qinghua Zhang, Shanpeng Wang, Xianjin Feng, Lin Gu, Hong Liu*, and Lin Han*, Low Lattice Mismatch InSe-Se Vertical Van der Waals Heterostructure for High-performance Transistors via Strong Fermi-level Depinning, Small Methods, 2020, 48202000238https://doi.org/10.1002/smtd.202000238.

  3. Jianfeng JiangYu Zhang, Aizhu Wang, Jiazhi Duan, Hao Ji, Jinbo Pang, Yuanhua Sang, Xianjin Feng, Hong Liu, Lin Han, Construction of high field-effect mobility multilayer MoS2 Field-effect transistors with excellent stability through interface engineering, ACS Applied Electronic Materials, 2020, 2(7), 2132-2140.

  4. Jianwei Gao, Yakun Gao , Yingkuan Han , Jinbo Pang, Wang Chao, Yanhao Wang, Hong Liu, Yu Zhang*, Lin Han*Ultrasensitive Label-free MiRNA Sensing Based on a Flexible Graphene Field-Effect Transistor without Functionalization, ACS Applied Electronic Materials, 2020, 1090-1098.

  5. Le Qiang, Yu Zhang*, Chao Wu, Yingkuan Han, Congcong Zhang, Guangzhou Liu, Qi Wu, Hong Liu, Suchun Wang, Yanyan Wang,  Ian R. Jenkinson,  Jun Sun* ,  Lin Han*, A Facile and Sensitive DNA Sensing of Harmful Algal Blooms Based on Graphene Oxide Nanosheets, Marine Biotechnology, https://doi.org/10.1007/s10126-020-09971-6.

  6. Le Qiang, Yu Zhang*, Xin Guo, Yakun Gao, Yingkuan Han, Jun Sun* & Lin Han*, A rapid and ultrasensitive colorimetric biosensor based on aptamer functionalized Au nanoparticles for detection of saxitoxin, RSC Advances, https://doi.org/10.1039/d0ra01231a.

  7. Yakun Gao , Le Qiang , Yujin Chu , Yingkuan Han , Yu Zhang* , and Lin Han*, Microfluidic chip for multiple detection of miRNA biomarkers in breast cancer based on three-segment hybridization, AIP Advances, https://doi.org/10.1063/1.5137784.

  8. Fulei Wang Jianfeng Jiang, Qilu Liu, Jianjun Wang, Shuhua Wang, Lin Han*, Hong Liu*, Yuanhua Sang*, Piezopotential gated two-dimensional InSe field-effect transistor for designing a pressure sensor based on piezotronic effect, Nano Energy, 2020, 70:104457.

  9. Min Hao, Jianlong He, Chunhua Wang, Chao Wang, Baojin Ma, Shan Zhang, Jiazhi Duan, Feng Liu, Yu Zhang, Lin Han*, Hong Liu*, and Yuanhua Sang*, Effect of hydroxyapatite nanorods on the fate of human adipose-derived stem cells assessed in Situ at the single cell level with a high-throughput, real-time microfluidic chip, Small, 2019,15(51),:1905001.

  10. Fulei Wang, Fuling Wang, Xiandi Wang, Shicai Wang, Jianfeng Jiang, Qilu Liu, Xiaotao Hao, Lin Han, Jianjun Wang, Caofeng Pan, Hong Liu, Yuanhua Sang, Mechanoluminescence enhancement of ZnS:Cu,Mn with piezotronic effect induced trap-depth reduction originated from PVDF ferroelectric film, Nano Energy, 2019, 63, 103861.

  11. Jianfeng Jiang, Qinghua Zhang, Aizhu Wang, Yu Zhang, Fanqi Meng, Congcong Zhang, Xianjin Feng, Yuanping Feng, Lin Gu*, Hong Liu*, and Lin Han*A Facile and Effective Method for Patching Sulfur Vacancies of WS2 via Nitrogen Plasma TreatmentSmall, June 18,2019 ,15(36): 1901791.

  12. Jianfeng Jiang, Jingxin Li, Yutao Li, Jiazhi Duan, Linshen Li, Ye Tian, Zhihua Zong, Haotian Zheng, Xianjin Feng, Qiqiang Li, Hong Liu, Yu Zhang, Tian-ling Ren*, Lin Han*Stable InSe Transistors with High-field Effect Mobility for Reliable Nerve Signal SensingNpj 2D Materials and Applications, July 4, 2019, 3:29.

  13. Le Qiang, Jing Guo, Yingkuan Han, Jianfeng Jiang, Xiaowen Su, Hong Liu, Qingguo Qi, Lin Han*, A novel anti Candida Albicans drug screening system based on high-throughput microfluidic chips, Scientific Reports, May 14, 2019, 9:8087

  14. Yingkuan Han, Hongxin Wang, Le Qiang, Yakun Gao, Qiqiang Li, Jinbo Pang, Hong Liu, Lin Han, Yu Wu, Yu Zhang, Fabrication of a uniform Au nanodot array/monolayer graphene hybrid structure for high-performance surface-enhanced Raman spectroscopy, Journal of Materials Science, 2020, 55(2):591-602, DOI: 10.1007/s10853-019-04036-z.

  15. Weidong Xu, Meng Xu, Jianfeng Jiang, Caina Luan, Lin Han, and Xianjin Feng, High performance thin film transistors with sputtered In-Al-Zn-O channel and different source/drain electrodes, IEEE Electron Device Letters, Jan. 1, 2019, 40(2):247-250 DOI: 10.1109/LED.2018.2890280

  16. Weidong Xu, Jianfeng Jiang, Sanjin Xu, Yu Zhang, Huayong Xu, Lin Han, Xianjin Feng, Effect of substrate temperature on sputtered indium-aluminum-zinc oxide films and thin film transistors, Journal of Alloys and Compounds, 2019, 791:773-778.

  17. Jiazhi Duan, Baojin Ma, Feng Liu, Shan Zhang, Shicai Wang, Ying Kong, Min Du, Lin Han*, Jianjun Wang*, Yuanhua Sang*, and Hong Liu*, Corrdination ability determined transition metal ions substitution of Tb in Tb-Asp fluorescent nanocrystals and a facile ions-detection approach, Nanoscale, 10:7526, 2018

  18. Hanbin Wang, Yiming Wang, Gengchang Zhu, Qingpu Wang, Qian Xin, Lin Han*, and Aimin Song*, A novel thermally evaporated etching mask for low-damage dry etching, IEEE Transactions on Nanotechnology, 16(2): 1-6, 2017

  19. L. Han, H. Wu, et al., Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single-cells, Nucleic Acids Research, 11:e77, Jan. 2017

  20. M. Kwak# , L. Han#, , J. Chen, R. Fan* , Interfacing Nanowire arrays and living cells for cellular functionanalysisSMALL; 11(42):226-228, 2015

  21. L. Han, X. Zi, et al., Co-detection and sequencing of genes and transcripts from the same single cells enabled by microfluidics platform, Scientific Reports, vol.4, p. 6485, 2014

  22. Kwak M. Kim DJ, Han L, Lee MR, Wu Y, Lee SK, and Fan R, Capture and multiplexed molecular typing of rare trafficking leukocytes via a biofunctionalized nanowire array, Nanoscale, vol.6(12), p. 6537, 2014

  23. W Chen, L.G. Villa-Diaz, L Han et al., nanotopography influences adhesion spreading, and self-renewal of human embryonic stem cells, ACS Nano (ACS Nano 2012) vol.6, p.4094, 2012

  24. SK Lee, GS Kim, L Han, et al., 2012, Nanowire Substrate-based Laser Scanning Cytometry for Quantitation of Circulating Tumor Cells, Nano Letters (Nano Letter 2012) vol.12, p.2697, 2012

  25. L. Han, Y. Huang, J.C. Sturm, and S. Wagner, “Self-aligned top-gate coplanar a-Si:H thin film transistors with a SiO2-silicone hybrid gate dielectric”, IEEE Electron Device Letters (EDL 2010), vol. 32, p. 36, 2010

  26. [Invited] L. Han, K. Song, P. Mandlik, and S. Wagner, “A new insulator for thin-film transistor backplanes and for flexible passivation layers”, Electrochemical Society Transaction (ECST 2010), vol. 33, p. 125, 2010

  27. L. Han, K. Song, P. Mandlik, and S. Wagner, “Ultraflexible amorphous silicon transistors made with a resilient insulator”, Applied Physics Letters, (APL 2010), vol. 96, pp. 042111, 2010

  28. L. Han, P. Mandlik, K. Cherenack and S. Wagner, “Amorphous silicon thin-film transistors with field effect mobilities of 2 cm2/V×s for electrons and 0.1 cm2/V×s for holes”, Applied Physics Letters, (APL 2009), vol. 94, pp. 162105, 2009

  29. L. Han, P. Mandlik and S. Wagner, “A new gate dielectric for highly stable amorphous-silicon thin-film transistors with 1.5 cm2/V×s electron field-effect mobility”, IEEE Electron Device Letters (EDL 2009), vol. 30, pp. 502, 2009

  30. L. Han, P. Mandlik, J. Gartside, S. Wagner, J. Silvernail, R. Ma, M. Mack and J. J. Brown, “Properties of a new permeation barrier material deposited from hexamethyl disiloxane and oxygen”, J. Electrochem. Soc., (JECS-2009), Vol. 156, pp. H106, 2009

  31. P. Mandlik, L. Han, S. Wagner, J. Silvernail, R. Ma, M. Hack and J. J. Brown, “Diffusion of atmospheric gases into barrier-layer sealed organic light emitting diodes”, Applied Physics Letters, (APL 2008), vol. 93, pp. 203306, 2008

  32. P. Mandlik,J. Gartside, L. Han, I. Chen, S. Wagner, J. Silvernail, R. Ma, M. Hack and J. J. Brown, “A single layer permeation barrier for organic light-emitting displays”, Applied Physics Letters, (APL 2008), vol. 92, pp. 103309, 2008


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